A PI3K Inhibitor with Low Cardiotoxicity and Its Synergistic Inhibitory Effect with Gilteritinib in Acute Myelogenous Leukemia (AML) Cells

A PI3K Inhibitor with Low Cardiotoxicity and Its Synergistic Inhibitory Effect with Gilteritinib in Acute Myelogenous Leukemia (AML) Cells

<i>N</i>-(2-chloro-5-(3-(pyridin-4-yl)-1H-pyrazolo [3,4-<i>b</i>]pyridin-5-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide, namely, FD274, is a promising 7-azaindazole-based PI3K inhibitor candidate with high antitumor efficacy against acute myeloid leukemia and reduced cardiotox...

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Bibliographic Details
Main Authors: Tianze Wu, Yi Chen, Yimin Gong, Mingzhu Lu, Chengbin Yang, Yannan Yang, Yun Ling, Yaming Zhou
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
7-azaindazole
PI3K inhibitor
cardiotoxicity
oxidative stress
acute myelogenous leukemia
combination therapy
Online Access:https://www.mdpi.com/1420-3049/30/11/2347
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