Identification of gut bacteria reductases that biotransform steroid hormones
Abstract The metabolism of steroid hormones by the gut microbiome is increasingly recognized as a key factor in human health; however, the specific enzymes mediating these transformations remain largely unidentified. In this study, we identify Δ4-3-ketosteroid 5β-reductase, 3β-hydroxysteroid dehydro...
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| Main Authors: | Gabriela Arp, Angela K. Jiang, Keith Dufault-Thompson, Sophia Levy, Aoshu Zhong, Jyotsna Talreja Wassan, Maggie R. Grant, Yue Li, Brantley Hall, Xiaofang Jiang |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61425-6 |
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