Identification of gut bacteria reductases that biotransform steroid hormones

Abstract The metabolism of steroid hormones by the gut microbiome is increasingly recognized as a key factor in human health; however, the specific enzymes mediating these transformations remain largely unidentified. In this study, we identify Δ4-3-ketosteroid 5β-reductase, 3β-hydroxysteroid dehydro...

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Bibliographic Details
Main Authors: Gabriela Arp, Angela K. Jiang, Keith Dufault-Thompson, Sophia Levy, Aoshu Zhong, Jyotsna Talreja Wassan, Maggie R. Grant, Yue Li, Brantley Hall, Xiaofang Jiang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61425-6
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