Chronic Fluoxetine Treatment Desensitizes Serotoninergic Inhibition of GABAergic Inputs and Intrinsic Excitability of Dorsal Raphe Serotonin Neurons

Chronic Fluoxetine Treatment Desensitizes Serotoninergic Inhibition of GABAergic Inputs and Intrinsic Excitability of Dorsal Raphe Serotonin Neurons

<b>Background:</b> Dorsal raphe serotonin (5-hydroxytryptamine, 5-HT) neurons are spontaneously active and release 5-HT that is critical for normal brain function and regulates mood and emotion. Serotonin reuptake inhibitors (SSRIs) increase the synaptic and extracellular 5-HT level and...

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Bibliographic Details
Main Authors: Wei Zhang, Ying Jin, Fu-Ming Zhou
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Brain Sciences
Subjects:
5-HT autoinhibition
antidepressant
dorsal raphe
G-protein-activated inwardly rectifying K (GirK) channel
neuroplasticity
selective serotonin reuptake inhibitor
Online Access:https://www.mdpi.com/2076-3425/15/4/384
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