Synergistic effects of MK-1775 and gemcitabine on cytotoxicity in non-small cell lung cancer

Synergistic effects of MK-1775 and gemcitabine on cytotoxicity in non-small cell lung cancer

Background: Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality. Chemotherapy is crucial in NSCLC treatment, and targeting Wee1 kinase, a key regulator of the G2/M cell cycle checkpoint, may enhance the efficacy of cytotoxic agents. This study investigates the pote...

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Bibliographic Details
Main Authors: Chiao-Ping Chen, Tsai-Hsien Hung, Ping-Chih Hsu, Chun-Nan Yeh, Wen-Kuan Huang, Yi-Ru Pan, Yu-Tien Hsiao, Chih-Hong Lo, Chiao-En Wu
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Heliyon
Subjects:
MK-1775
Non-small cell lung cancer
Chemotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402416330X
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http://www.sciencedirect.com/science/article/pii/S240584402416330X

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