Effect of Low-Dose Hormone Therapy on Metabolic Parameters and Bone Mineral Density
OBJECTIVE: Early menopause causes several health concerns that are related directly to the deficiency of ovarian hormones, especially estrogen insufficiency. The purpose of the research was to investigate the impact of low-dose hormone therapy on metabolic parameters and bone densitometry in patien...
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| Format: | Article |
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Medical Network
2024-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1520 |
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| author | Ufuk Atlihan Onur Yavuz Huseyin Aytug Avsar Can Ata Tevfik Berk Bildaci Selcuk Erkilinc |
| author_facet | Ufuk Atlihan Onur Yavuz Huseyin Aytug Avsar Can Ata Tevfik Berk Bildaci Selcuk Erkilinc |
| author_sort | Ufuk Atlihan |
| collection | DOAJ |
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OBJECTIVE: Early menopause causes several health concerns that are related directly to the deficiency of ovarian hormones, especially estrogen insufficiency. The purpose of the research was to investigate the impact of low-dose hormone therapy on metabolic parameters and bone densitometry in patients with early menopause.
STUDY DESIGN: A total of 98 patients aged 38-42 years with an early-menopause and followed up were evaluated retrospectively in this cohort study. After the diagnosis of early menopause, combined oral contraceptive (COC) treatment including 3 mg Drospirenone + 0.02 mg Ethinylestradiol was recommended to the patients. After 1 year of COC treatment, metabolic, ultrasonographic, and bone densitometry measurements of patients who did and did not use COC regularly were compared.
RESULTS: At the 12th-month follow-up, endometrial thickness was significantly higher in the COC group (3.8±0.4 mm) compared with the non-COC group (3.5±0.4 mm) (p<0.01). At the 12th month follow-up, the estradiol value was significantly higher (16.1±1.5 pg/mL) in the COC group compared with the non-COC group (14.8±2.5 pg/mL) (p<0.01). At the 12th month follow-up, the total cholesterol value was found significantly lower in the COC group (197±24.2 mg/dL) compared with the non-COC group (211±28 mg/dL) (p<0.01). At the 12th month follow-up, the Z-score was found significantly higher in the COC group (0.02±0.3) compared with the non-COC group (0.2±0.3) (p<0.01).
CONCLUSION: Hormone replacement therapy is very important for women who enter early menopause, and adequate estrogen therapy must be taken to maintain bone density and reduce menopausal symptoms.
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| format | Article |
| id | doaj-art-f413466319974d4fad1b9202c1c48010 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-f413466319974d4fad1b9202c1c480102025-02-11T21:19:01ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182024-12-0130310.21613/GORM.2023.1520Effect of Low-Dose Hormone Therapy on Metabolic Parameters and Bone Mineral DensityUfuk Atlihan0Onur Yavuz1Huseyin Aytug Avsar2Can Ata3Tevfik Berk Bildaci4Selcuk Erkilinc5Private Karatas Hospital, Department of Gynecology and ObstetricsDokuz Eylul University, Institute of Health Sciences, Department of Gynecology and ObstetricsBuca Seyfi Demirsoy Training and Research Hospital, Department of Gynecology and ObstetricsBuca Seyfi Demirsoy Training and Research Hospital, Department of Gynecology and Obstetricsİzmir Democracy University, Institute of Health Sciences, Department of Gynecology and Obstetricsİzmir Democracy University, Institute of Health Sciences, Department of Gynecology and Obstetrics OBJECTIVE: Early menopause causes several health concerns that are related directly to the deficiency of ovarian hormones, especially estrogen insufficiency. The purpose of the research was to investigate the impact of low-dose hormone therapy on metabolic parameters and bone densitometry in patients with early menopause. STUDY DESIGN: A total of 98 patients aged 38-42 years with an early-menopause and followed up were evaluated retrospectively in this cohort study. After the diagnosis of early menopause, combined oral contraceptive (COC) treatment including 3 mg Drospirenone + 0.02 mg Ethinylestradiol was recommended to the patients. After 1 year of COC treatment, metabolic, ultrasonographic, and bone densitometry measurements of patients who did and did not use COC regularly were compared. RESULTS: At the 12th-month follow-up, endometrial thickness was significantly higher in the COC group (3.8±0.4 mm) compared with the non-COC group (3.5±0.4 mm) (p<0.01). At the 12th month follow-up, the estradiol value was significantly higher (16.1±1.5 pg/mL) in the COC group compared with the non-COC group (14.8±2.5 pg/mL) (p<0.01). At the 12th month follow-up, the total cholesterol value was found significantly lower in the COC group (197±24.2 mg/dL) compared with the non-COC group (211±28 mg/dL) (p<0.01). At the 12th month follow-up, the Z-score was found significantly higher in the COC group (0.02±0.3) compared with the non-COC group (0.2±0.3) (p<0.01). CONCLUSION: Hormone replacement therapy is very important for women who enter early menopause, and adequate estrogen therapy must be taken to maintain bone density and reduce menopausal symptoms. https://gorm.com.tr/index.php/GORM/article/view/1520: Early menopauseHormone Replacement TherapyPremature ovarian failure |
| spellingShingle | Ufuk Atlihan Onur Yavuz Huseyin Aytug Avsar Can Ata Tevfik Berk Bildaci Selcuk Erkilinc Effect of Low-Dose Hormone Therapy on Metabolic Parameters and Bone Mineral Density Gynecology Obstetrics & Reproductive Medicine : Early menopause Hormone Replacement Therapy Premature ovarian failure |
| title | Effect of Low-Dose Hormone Therapy on Metabolic Parameters and Bone Mineral Density |
| title_full | Effect of Low-Dose Hormone Therapy on Metabolic Parameters and Bone Mineral Density |
| title_fullStr | Effect of Low-Dose Hormone Therapy on Metabolic Parameters and Bone Mineral Density |
| title_full_unstemmed | Effect of Low-Dose Hormone Therapy on Metabolic Parameters and Bone Mineral Density |
| title_short | Effect of Low-Dose Hormone Therapy on Metabolic Parameters and Bone Mineral Density |
| title_sort | effect of low dose hormone therapy on metabolic parameters and bone mineral density |
| topic | : Early menopause Hormone Replacement Therapy Premature ovarian failure |
| url | https://gorm.com.tr/index.php/GORM/article/view/1520 |
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