Calpain1 inhibition enhances autophagy-lysosomal pathway and ameliorates tubulointerstitial fibrosis in Nephronophthisis

Calpain1 inhibition enhances autophagy-lysosomal pathway and ameliorates tubulointerstitial fibrosis in Nephronophthisis

Abstract Background Nephronophthisis (NPH) is classified under the category of renal ciliopathies and is the most common genetic disease leading to renal failure in children. Early-onset and progressive renal tubulointerstitial fibrosis represents one of the most significant features, culminating in...

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Main Authors: Dantong Li, Jinglan Zhang, Xinyu Su, Yichen Yang, Jiayong Lai, Xiaoya Wei, Huamu Chen, Yaqing Liu, Haiyan Wang, Liangzhong Sun
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
Calpain1
Renal ciliopathies
Renal tubulointerstitial fibrosis
Inherited kidney disease
Nephronophthisis
Online Access:https://doi.org/10.1186/s10020-025-01231-4
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https://doi.org/10.1186/s10020-025-01231-4

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