Development of mercapto-phenyl-1,2,4-triazole bearing thio-quinoline as a novel class of tyrosinase inhibitors: an in vitro and in silico study

Development of mercapto-phenyl-1,2,4-triazole bearing thio-quinoline as a novel class of tyrosinase inhibitors: an in vitro and in silico study

Abstract In this study, a novel series of mercapto-phenyl-1,2,4-triazole-bearing thio-quinoline moieties was designed, synthesized, and evaluated for their anti-tyrosinase activities. All compounds were tested for inhibitory activity against tyrosinase, compound 12j was found to be the most potent w...

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Main Authors: Nazanin Motamedi Shakib, Mohammad Hosein Sayahi, Najmeh Oliyaei, Milad Noori, Navid Dastyafteh, Mohammad Mahdavi, Bagher Larijani, Parviz Rashidi Ranjbar, Aida Iraji
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Thio-quinoline
Phenyl-1,2,4-triazole
Tyrosinase inhibitors
Structure–activity relationship
Molecular docking
Molecular dynamics simulation
Online Access:https://doi.org/10.1038/s41598-025-09072-1
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https://doi.org/10.1038/s41598-025-09072-1

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