Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization

During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death. Here we have assessed the role of caspases, Bcl-2 family members and the mitochondrial permeability transition pore on ER stress-induced MOMP and sub...

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Bibliographic Details
Main Authors: Sanjeev Gupta, Lorraine Cuffe, Eva Szegezdi, Susan E. Logue, Catherine Neary, Sandra Healy, Afshin Samali
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:International Journal of Cell Biology
Online Access:http://dx.doi.org/10.1155/2010/170215
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