Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats
The present study aimed to clarify the role of mast cells in colitis with relapse induced in Wistar rats by trinitrobenzenosulphonic acid. Colitis induction increased the histamine concentration in the colon, w...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/432493 |
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| Summary: | The present study aimed to clarify the role of mast cells in colitis with
relapse induced in Wistar rats by trinitrobenzenosulphonic
acid. Colitis induction increased the histamine concentration
in the colon, which peaked on day 26. The number of mast cells,
probably immature, was ten times higher on day 8. Different from
animals infected with intestinal parasites, after colitis remission,
mast cells do not migrate to the spleen, showing that mast cell
proliferation presents different characteristics depending on the
inflammation stimuli. Treatment with sulfasalazine, doxantrazole,
quercetin, or nedocromil did not increase the histamine concentration
or the mast cell number in the colon on day 26, thereby showing
absence of degranulation of these cells. In conclusion, although mast
cell proliferation is associated with colitis, these cells and their
mediators appear to play no clear role in the colitis with
relapses. |
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| ISSN: | 0962-9351 1466-1861 |