Kinome profiling reveals pathogenic variant specific protein signalling networks in MEN2 children with Medullary Thyroid Cancer

Kinome profiling reveals pathogenic variant specific protein signalling networks in MEN2 children with Medullary Thyroid Cancer

Abstract Multiple Endocrine Neoplasia Type 2 (MEN2) is an autosomal dominant disease caused by pathogenic variants in the receptor tyrosine kinase RET, with strong genotype-phenotype correlations. The development and progression of these tumours are not always predictable even within families with t...

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Main Authors: B. Rix, R. Chauhan, Z. Masoumi, E. Grönroos, C. E. Brain, O. K. Ogunbiyi, K. Swarbrick, C. Swanton, D. Bonnet, T. R. Kurzawinski, L. Izatt, N. Q. McDonald, W. Grey
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00919-4
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https://doi.org/10.1038/s41698-025-00919-4

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