Intra-tumoral administration of CHST15 siRNA remodels tumor microenvironment and augments tumor-infiltrating T cells in pancreatic cancer

Intra-tumoral administration of CHST15 siRNA remodels tumor microenvironment and augments tumor-infiltrating T cells in pancreatic cancer

The dense stroma is one cause of poor efficacy of T cell-mediated immunotherapy in pancreatic ductal adenocarcinoma (PDAC). Carbohydrate sulfotransferase 15 (CHST15) is a proteoglycan-synthetic enzyme responsible for remodeling tumor stroma. Intra-tumoral injection of CHST15 small interfering RNA (s...

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Bibliographic Details
Main Authors: Juanjuan Ye, Futoshi Suizu, Keiko Yamakawa, Yuri Mukai, Hiroyuki Yoneyama, Jiro Kondo, Motohiko Kato, Akira Nishiyama, Naohisa Yahagi, Kyuichi Kadota
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
pancreatic ductal adenocarcinoma
PDAC
oligonucleotide
tumor-draining lymph node
TDLN
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000547
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http://www.sciencedirect.com/science/article/pii/S2950329924000547

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