Clusterin facilitates glioma progression via BCL2L1-dependent regulation of apoptotic resistance

Clusterin facilitates glioma progression via BCL2L1-dependent regulation of apoptotic resistance

BackgroundClusterin (CLU) is a multifunctional protein involved in various pathophysiological processes and diseases. Glioma, the most common aggressive primary brain tumor, is characterized by high morbidity, mortality, and extremely poor prognosis. Our research has found that CLU is upregulated in...

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Main Authors: Qingqing Xu, Xin Liu, Yibo Zhang, Shiyu Yuan, Wenli Huang, Mingshan Pi, Qi Xiong, Hongyan Zhou, Yuran Gui, Yifan Xiao, Xiaochuan Wang, Xiji Shu, Yiyuan Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
glioma
clusterin (CLU)
migration
proliferation
BCL2L1
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1596021/full
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https://www.frontiersin.org/articles/10.3389/fnmol.2025.1596021/full

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