Noscapine derivative 428 suppresses ferroptosis through targeting GPX4

Noscapine derivative 428 suppresses ferroptosis through targeting GPX4

Inhibiting ferroptosis represents a promising strategy to combat ferroptosis-related diseases. Here we show that 428, a selenide-containing noscapine derivative, effectively inhibits ferroptosis in various cell lines by enhancing the stability and activity of GPX4. TRIM41 was identified as a novel E...

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Bibliographic Details
Main Authors: Youping Zhang, Haoliang Shi, Yingying Wang, Wanting Liu, Guanyi Li, Defeng Li, Wenxuan Wu, Yunzhao Wu, Ziwei Zhang, Yanjie Ji, Chujiao Zhu, Wenhui Bai, Hu Lei, Hanzhang Xu, Hua Zhong, Baohui Han, Li Yang, Ligen Liu, Wei Wang, Yaxue Zhao, Yongqiang Zhang, Yingli Wu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Redox Biology
Subjects:
Ferroptosis
GPX4
Noscapine derivative
Idiopathic pulmonary fibrosis
Selenocysteine
TRIM41
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172500148X
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