N-aldehyde-modified phosphatidylethanolamines generated by lipid peroxidation are robust substrates of N-acyl phosphatidylethanolamine phospholipase D

N-aldehyde-modified phosphatidylethanolamines generated by lipid peroxidation are robust substrates of N-acyl phosphatidylethanolamine phospholipase D

N-acyl phosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD) hydrolyzes phosphatidylethanolamines (PEs) where the headgroup nitrogen has been enzymatically modified with acyl chains of four carbons or longer (N-acyl-PEs or NAPEs). The nitrogen headgroup of PE can also be nonenzymatically m...

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Bibliographic Details
Main Authors: Reza Fadaei, Annie C. Bernstein, Andrew N. Jenkins, Allison G. Pickens, Jonah E. Zarrow, Abdul-Musawwir Alli-Oluwafuyi, Keri A. Tallman, Sean S. Davies
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Lipid Research
Subjects:
reactive lipid aldehydes
lipid peroxidation
phospholipases
phosphatidylethanolamine
N-acyl-ethanolamines
oxidized phospholipids
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525000914
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