Multi-omics analysis reveals immunosuppression in oesophageal squamous cell carcinoma induced by creatine accumulation and HK3 deficiency

Multi-omics analysis reveals immunosuppression in oesophageal squamous cell carcinoma induced by creatine accumulation and HK3 deficiency

Abstract Background Deep insights into the metabolic remodelling effects on the immune microenvironment of oesophageal squamous cell carcinoma (ESCC) are crucial for advancing precision immunotherapies and targeted therapies. This study aimed to provide novel insights into the molecular landscape of...

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Main Authors: Yingzhen Gao, Siyu He, Xiaoyan Meng, Kun Zheng, Heyang Cui, Yikun Cheng, Xinyuan Shen, Yuanfang Zhai, Binbin Zou, Fang Wang, Hongyi Li, Pengzhou Kong, Yanqiang Wang, Xuefei Feng, Bin Yang, Ruifang Sun, Yongsheng Meng, Enwei Xu, Yanlin Guo, Ning Ding, Weimin Zhang, Xiaolong Cheng, Lunzhi Dai, Yongping Cui, Ling Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Genome Medicine
Subjects:
Oesophageal squamous cell carcinoma
Multi-omics
Creatine
Hexokinase 3
Subtypes
Proteomics
Online Access:https://doi.org/10.1186/s13073-025-01465-1
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https://doi.org/10.1186/s13073-025-01465-1

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