The neuroepithelial origin of ovarian carcinomas explained through an epithelial-mesenchymal-ectodermal transition enhanced by cisplatin

The neuroepithelial origin of ovarian carcinomas explained through an epithelial-mesenchymal-ectodermal transition enhanced by cisplatin

Abstract Acquired resistance to platinum-derived cytostatics poses major challenges in ovarian carcinoma therapy. In this work, we show a shift in the epithelial-mesenchymal transition (EMT) process towards an “ectodermal” conversion of ovarian carcinoma cells in response to cisplatin treatment, a p...

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Main Authors: David Díaz-Carballo, Ayesha Safoor, Sahitya Saka, Adrien Noa-Bolaño, Flevy D’Souza, Jacqueline Klein, Ali H. Acikelli, Sascha Malak, Udo Rahner, Amin T. Turki, Anne Höppner, Annabelle Kamitz, Wanlu Song, Ye-guang Chen, Lalitha Kamada, Andrea Tannapfel, Sebastian Brinkmann, Crista Ochsenfarth, Dirk Strumberg
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Tumor cell heterogeneity
Cancer stem cells
CSC markers
Online Access:https://doi.org/10.1038/s41598-024-76984-9
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https://doi.org/10.1038/s41598-024-76984-9

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