High‐throughput, microscope‐based sorting to dissect cellular heterogeneity

High‐throughput, microscope‐based sorting to dissect cellular heterogeneity

Abstract Microscopy is a powerful tool for characterizing complex cellular phenotypes, but linking these phenotypes to genotype or RNA expression at scale remains challenging. Here, we present Visual Cell Sorting, a method that physically separates hundreds of thousands of live cells based on their...

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Bibliographic Details
Main Authors: Nicholas Hasle, Anthony Cooke, Sanjay Srivatsan, Heather Huang, Jason J Stephany, Zachary Krieger, Dana Jackson, Weiliang Tang, Sriram Pendyala, Raymond J Monnat, Cole Trapnell, Emily M Hatch, Douglas M Fowler
Format: Article
Language:English
Published: Springer Nature 2020-06-01
Series:Molecular Systems Biology
Subjects:
genetic screening
microscopy
pharmacology
subcellular localization
transcriptomics
Online Access:https://doi.org/10.15252/msb.20209442
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https://doi.org/10.15252/msb.20209442

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