Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish

Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish

Previously, we showed that propranolol reduces experimental murine cerebral cavernous malformations (CCMs) and prevents embryonic caudal venous plexus (CVP) lesions in zebrafish that follow mosaic inactivation of ccm2 (Li et al., 2021). Because morpholino silencing of the β1 adrenergic receptor (adr...

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Bibliographic Details
Main Authors: Wenqing Li, Sara McCurdy, Miguel A Lopez-Ramirez, Ho-Sup Lee, Mark H Ginsberg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
vascular biology
cerebral cavernous malformation
beta1 adrenergic receptor
beta1 selective antagonist
Online Access:https://elifesciences.org/articles/99455
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https://elifesciences.org/articles/99455

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