Untargeted metabolomics-based elucidation of metabolic reprogramming mechanisms and pathways following aortic dissection surgery

Untargeted metabolomics-based elucidation of metabolic reprogramming mechanisms and pathways following aortic dissection surgery

Abstract Background Postoperative complications persist in acute DeBakey type I aortic dissection (AD) despite surgical advances, yet the underlying metabolic mechanisms remain unexplored. This knowledge gap critically limits targeted interventions. Methods Untargeted metabolomics using ultra-high-p...

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Bibliographic Details
Main Authors: Jun He, Yuji Xiao, Wanru Ma, Yaoguang Feng, Chengming Ding, Haonan Zhang, Heng Yang, Zhengwen Lei
Format: Article
Language:English
Published: BMC 2025-07-01
Series:European Journal of Medical Research
Subjects:
Untargeted metabolomics
Acute DeBakey Type I Aortic Dissection
Metabolic reprogramming
Lipid homeostasis remodeling
Energy metabolism optimization
Oxidative defense network
Online Access:https://doi.org/10.1186/s40001-025-02924-6
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https://doi.org/10.1186/s40001-025-02924-6

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