Discrimination of SNPs in GC-rich regions using a modified hydrolysis probe chemistry protocol

Allelic discrimination using TaqMan 5′-nuclease assay chemistry has been in routine use for many years, and the catalog of Life Technologies— predesigned SNP genotyping assays now exceeds 4 million entries. However, predesigned assays are often not available for genomic regions with a high GC conten...

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Bibliographic Details
Main Authors: Alireza Mowjoodi, Tara A. Paton, Stephen W. Scherer
Format: Article
Language:English
Published: Taylor & Francis Group 2014-12-01
Series:BioTechniques
Subjects:
Online Access:https://www.future-science.com/doi/10.2144/000114240
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