In vitro and in vivo evaluation of immortalized hepatocyte encapsulated click-microbeads with RGD peptide for treatment of liver failure in male rats

In vitro and in vivo evaluation of immortalized hepatocyte encapsulated click-microbeads with RGD peptide for treatment of liver failure in male rats

Cell encapsulation in biocompatible microbeads offers a promising strategy for cell-based therapy in acute liver failure (ALF). This study evaluates the use of immortalized hepatocyte cells (imHCs) encapsulated in click-arginyl glycyl aspartic acid (click-RGD)-modified alginate microbeads, focusing...

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Bibliographic Details
Main Authors: Su Yee Win, Pinunta Nittayacharn, Jatupoom Ngernmark, Mongkol Chavalitsarot, Chitinart Thedrattanawong, Khanit Sa-ngiamsuntorn, Suradej Hongeng, Norased Nasongkla
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
cell encapsulation
immortalized hepatocytes
click-RGD microbeads
acute liver failure
in vivo
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1629228/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2025.1629228/full

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