Toward a deeper understanding of dengue: novel method for quantification and isolation of envelope protein epitope-specific antibodies

Toward a deeper understanding of dengue: novel method for quantification and isolation of envelope protein epitope-specific antibodies

ABSTRACT The dengue viruses (DENV) envelope (E) protein is the main target of the antibody (Ab) response. Abs target different epitopes on the E-protein, including sE-dimer, E domain III (EDIII), and fusion loop (FL). Anti-EDIII Abs are mainly serotype-specific, whereas anti-FL Abs can induce antibo...

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Main Authors: Sokchea Lay, Candice Bohaud, Sopheak Sorn, Sreymom Ken, Felix A. Rey, Kevin K. Ariën, Sowath Ly, Veasna Duong, Giovanna Barba-Spaeth, Heidi Auerswald, Tineke Cantaert
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mSphere
Subjects:
dengue virus
antibody response to dengue
antibody-dependent enhancement
flavivirus anti-envelope antibodies
Online Access:https://journals.asm.org/doi/10.1128/msphere.00961-24
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https://journals.asm.org/doi/10.1128/msphere.00961-24

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