A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosisResearch in context

A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosisResearch in context

Summary: Background: SOD1 mutations are a significant contributor of familial amyotrophic lateral sclerosis (ALS) cases. SOD1 mutations increase the propensity for the protein to misfold and aggregate into insoluble proteinaceous deposits within motor neurons and neighbouring cells. The small molec...

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Main Authors: Jeremy S. Lum, Mikayla L. Brown, Natalie E. Farrawell, Rachael Bartlett, Christen G. Chisholm, Jody Gorman, Anthony Dosseto, Florian Dux, Lachlan E. McInnes, Heath Ecroyd, Luke McAlary, Peter J. Crouch, Paul S. Donnelly, Justin J. Yerbury
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:EBioMedicine
Subjects:
SOD1
Amyotrophic lateral sclerosis
Motor neuron disease
Polytherapy
CuATSM
Ebselen
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425001367
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