Senescence-associated secretory phenotype in lung cancer: remodeling the tumor microenvironment for metastasis and immune suppression

Senescence-associated secretory phenotype in lung cancer: remodeling the tumor microenvironment for metastasis and immune suppression

Cellular senescence exerts dual roles in lung cancer pathogenesis: initially suppressing tumorigenesis via p53/p21/p16-mediated cell cycle arrest, but promoting malignancy through the senescence-associated secretory phenotype (SASP). SASP secretes cytokines, proteases, and growth factors, reshaping...

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Bibliographic Details
Main Authors: Chen Chen, Ji Chen, Yanling Zhang, Qijun Zhang, Haixia Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
cellular senescence
lung cancer
SASP
therapy resistance
precision medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1605085/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1605085/full

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