Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery

Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery

The influenza virus glycoprotein hemagglutinin (HA) participates in critical steps of the attachment of viral particles to the host cell membrane receptor and membrane fusion. Due to its crucial involvement in the initial phases of influenza A infections, HA emerges as a promising target in the sear...

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Bibliographic Details
Main Authors: Francisco Javier Hermoso-Pinilla, Aitor Valdivia, María-José Camarasa, Tiziana Ginex, Francisco Javier Luque
Format: Article
Language:English
Published: Open Exploration 2024-02-01
Series:Exploration of Drug Science
Subjects:
influenza a virus
hemagglutinin
fusion inhibitors
drug design
targeted protein degradation
antiviral proteolysis targeting chimeras
Online Access:https://www.explorationpub.com/uploads/Article/A100837/100837.pdf
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