Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast

Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast

ABSTRACT Inositol pyrophosphates 5-IP7, 1-IP7, and 1,5-IP8 are eukaryal signaling molecules that influence cell physiology, especially phosphate homeostasis. In fission yeast, 1,5-IP8 and 1-IP7 impact gene expression by acting as agonists of RNA 3'-processing and transcription termination. 1,5-...

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Main Authors: Beate Schwer, Isabel Prucker, Ana M. Sanchez, Jill Babor, Henning J. Jessen, Stewart Shuman
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
Schizosaccharomyces pombe
inositol pyrophosphates
pyrophosphatases
Online Access:https://journals.asm.org/doi/10.1128/mbio.00389-25
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https://journals.asm.org/doi/10.1128/mbio.00389-25

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