Limbic system synaptic dysfunctions associated with prion disease onset

Limbic system synaptic dysfunctions associated with prion disease onset

Abstract Misfolding of normal prion protein (PrPC) to pathological isoforms (prions) causes prion diseases (PrDs) with clinical manifestations including cognitive decline and mood-related behavioral changes. Cognition and mood are linked to the neurophysiology of the limbic system. Little is known a...

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Main Authors: Simote T. Foliaki, Bradley R. Groveman, Emmett A. Dews, Katie Williams, Hadil El Soufi, Benjamin Schwarz, Jacqueline M. Leung, Christine A. Schneider, Cindi L. Schwartz, Eric Bohrnsen, Cole D. Kimzey, Brent Race, Cathryn L. Haigh
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Acta Neuropathologica Communications
Subjects:
Prion disease
Synaptic transmission
Neurodegeneration
Limbic system
Cognition
Emotion
Online Access:https://doi.org/10.1186/s40478-024-01905-w
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https://doi.org/10.1186/s40478-024-01905-w

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