Direct genetic transformation bypasses tumor-associated DNA methylation alterations

Direct genetic transformation bypasses tumor-associated DNA methylation alterations

Abstract Background Tumors represent dynamically evolving populations of mutant cells, and many advances have been made in understanding the biology of their progression. However, there are key unresolved questions about the conditions that support a cell’s initial transformation, which cannot be ea...

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Main Authors: Sara Hetzel, Eran Hodis, Elena Torlai Triglia, Alexander Kovacsovics, Kathleen Steinmann, Andreas Gnirke, Meiying Cui, Daniel McQuaid, Raha Weigert, Georg Pohl, Mandar D. Muzumdar, Serge Leyvraz, Ulrich Keilholz, Marie-Laure Yaspo, Aviv Regev, Helene Kretzmer, Zachary D. Smith, Alexander Meissner
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Genome Biology
Subjects:
DNA methylation
Cancer
Epigenetics
Disease models
Genetically engineered mouse models
Online Access:https://doi.org/10.1186/s13059-025-03650-2
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https://doi.org/10.1186/s13059-025-03650-2

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