Nucleoside diphosphate kinase strongly promotes GDP and ADP metabolism in the cell and affects endogenous proton leak in mitochondria – the kinase is hampered by oxidative phosphorylation inhibitors

Nucleoside diphosphate kinase strongly promotes GDP and ADP metabolism in the cell and affects endogenous proton leak in mitochondria – the kinase is hampered by oxidative phosphorylation inhibitors

Rapid GDP metabolism in mitochondria isolated from wild-type yeast is postulated. The hallmark of exogenous GDP is convergence with the effect of exogenous ADP, typically inducing oxidative phosphorylation (OXPHOS). The GDP-provoked changes in the presence of ATP, i.e. increased respiratory rate acc...

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Bibliographic Details
Main Author: Andrzej M. Woyda-Ploszczyca
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
ADP/ATP carrier
nucleotide metabolism
mitochondria
nucleoside-diphosphate kinase (NDPK)
proton (H+) leak
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2025.2520611
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https://www.tandfonline.com/doi/10.1080/14756366.2025.2520611

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