Ginsenoside Rb1 mitigates atherosclerosis in part through modulating FTO-mediated m6A RNA modification in NETs-induced endothelial activation

Ginsenoside Rb1 mitigates atherosclerosis in part through modulating FTO-mediated m6A RNA modification in NETs-induced endothelial activation

BackgroundGinsenoside Rb1 (Rb1) exerts pharmacological effects in attenuating the progression of atherosclerosis. However, whether the anti-atherosclerotic effects of Rb1 involve suppressing neutrophil extracellular traps (NETs)-induced endothelial activation and whether N6-methyadenosine (m6A) RNA...

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Bibliographic Details
Main Authors: Zhenni Yang, Minqi Xiong, Xinmiao Tang, Peiwei Wang, Jingang Cui, Yu Chen, Teng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
Ginsenoside Rb1
atherosclerosis
endothelial activation
neutrophil extracellular traps
fat mass and obesity-associated protein
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1631076/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1631076/full

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