Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation.

Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation.

BRAF functions in the RAS-extracellular signal-regulated kinase (ERK) signaling cascade. Activation of this pathway is necessary to mediate the transforming potential of oncogenic BRAF, however, it may also cause a negative feedback that inhibits the epidermal growth factor receptor (EGFR). Mitogen-...

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Main Authors: Malgorzata Milewska, David Romano, Ana Herrero, Maria Luisa Guerriero, Marc Birtwistle, Franz Quehenberger, Stefan Hatzl, Boris N Kholodenko, Oreste Segatto, Walter Kolch, Armin Zebisch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0129859&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0129859&type=printable

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