Discovery of Potent Dengue Virus NS2B-NS3 Protease Inhibitors Among Glycyrrhizic Acid Conjugates with Amino Acids and Dipeptides Esters

Discovery of Potent Dengue Virus NS2B-NS3 Protease Inhibitors Among Glycyrrhizic Acid Conjugates with Amino Acids and Dipeptides Esters

This study investigated a library of known and novel glycyrrhizic acid (GL) conjugates with amino acids and dipeptide esters, as inhibitors of the DENV NS2B-NS3 protease. We utilized docking algorithms to evaluate the interactions of these GL derivatives with key residues (His51, Asp75, Ser135, and...

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Main Authors: Yu-Feng Lin, Hsueh-Chou Lai, Chen-Sheng Lin, Ping-Yi Hung, Ju-Ying Kan, Shih-Wen Chiu, Chih-Hao Lu, Svetlana F. Petrova, Lidia Baltina, Cheng-Wen Lin
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Viruses
Subjects:
glycyrrhizic acid
conjugates
amino acids
dipeptides
synthesis
antiviral activity
Online Access:https://www.mdpi.com/1999-4915/16/12/1926
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