miRNA-338-3p influences the liver cancer stem cells and lenvatinib resistance properties by targeting SOX4

Abstract Cancer stem cells (CSCs) are critical players in the pathogenesis of human-associated cancers. It is well established that the stemness of CSCs is modulated by microRNA (miRNA). In the current study, the miR-338-3p deficiency increased self-renewal and tumor malignancy in hepatic CSCs. Neve...

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Bibliographic Details
Main Authors: Ying Yuan, Hui-fen Li, Zi-mei Liu, Li-ping Yu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-06805-0
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