Late-onset Leber’s hereditary optic neuropathy and antiandrogens for prostate cancer: is there a causative link?

Late-onset Leber’s hereditary optic neuropathy and antiandrogens for prostate cancer: is there a causative link?

IntroductionLeber’s hereditary optic neuropathy (LHON) is a maternally inherited condition due to mitochondrial DNA (mtDNA) mutations usually affecting young men within their thirties, while women seem protected by estrogens with a female-to-male ratio of 1:3. Late-onset cases (over 40 years of age)...

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Main Authors: Giulia Amore, Michele Carbonelli, Diego D’Angeli, Luigi Bonan, Marco Faustini-Fustini, Alessandra Maresca, Valerio Carelli, Chiara La Morgia
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Neurology
Subjects:
Leber’s hereditary optic neuropathy
hormones
mitochondrial disease
androgen deprivation therapy
estrogens
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1616992/full
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https://www.frontiersin.org/articles/10.3389/fneur.2025.1616992/full

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