SLFN11 Restricts LINE-1 Mobility

SLFN11 Restricts LINE-1 Mobility

Long interspersed element-1 (LINE-1) is the only active autonomous transposon comprising about 17% of human genomes. LINE-1 transposition can cause the mutation and rearrangement of the host’s genomic DNA. The host has, therefore, developed multiple mechanisms to restrict LINE-1 mobility. Here, we r...

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Bibliographic Details
Main Authors: Zhongjie Ye, Yuqing Duan, Ao Zhang, Zixiong Zhang, Saisai Guo, Qian Liu, Dongrong Yi, Xinlu Wang, Jianyuan Zhao, Quanjie Li, Ling Ma, Jiwei Ding, Shan Cen, Xiaoyu Li
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
long interspersed element-1
LINE-1
transposon
SLFN11
helicase
RNA polymerase II
Online Access:https://www.mdpi.com/2073-4409/14/11/790
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