Acute Cardiogenic Shock Induced by Infusional 5-Fluorouracil

A 49-year-old patient with metastatic carcinoma of the bladder and no prior history of heart disease presented with diffuse ST elevation, elevated troponins, and biventricular dysfunction requiring intensive care unit admission and inotropic support after receiving her first course of infusional 5-f...

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Main Authors: Jeffrey Sulpher, Franco Dattilo, Susan Dent, Michele Turek, M. Neil Reaume, Christopher Johnson
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Case Reports in Oncological Medicine
Online Access:http://dx.doi.org/10.1155/2014/819396
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author Jeffrey Sulpher
Franco Dattilo
Susan Dent
Michele Turek
M. Neil Reaume
Christopher Johnson
author_facet Jeffrey Sulpher
Franco Dattilo
Susan Dent
Michele Turek
M. Neil Reaume
Christopher Johnson
author_sort Jeffrey Sulpher
collection DOAJ
description A 49-year-old patient with metastatic carcinoma of the bladder and no prior history of heart disease presented with diffuse ST elevation, elevated troponins, and biventricular dysfunction requiring intensive care unit admission and inotropic support after receiving her first course of infusional 5-fluorouracil (5-FU). Over the course of several days, the patient’s cardiac function and clinical status returned to baseline. A follow-up echocardiogram performed 5 days after initial presentation revealed an ejection fraction of 59 percent, with no evidence of wall motion abnormalities. Subsequent 5-FU chemotherapy was discontinued, and the patient went on to receive second-line chemotherapy.
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publishDate 2014-01-01
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series Case Reports in Oncological Medicine
spelling doaj-art-f2416804e86742e2a1892236030013702025-02-03T01:02:43ZengWileyCase Reports in Oncological Medicine2090-67062090-67142014-01-01201410.1155/2014/819396819396Acute Cardiogenic Shock Induced by Infusional 5-FluorouracilJeffrey Sulpher0Franco Dattilo1Susan Dent2Michele Turek3M. Neil Reaume4Christopher Johnson5Division of Medical Oncology, The Ottawa Hospital, Ottawa, ON, K1H 8L6, CanadaDivision of Medical Oncology, The Ottawa Hospital, Ottawa, ON, K1H 8L6, CanadaDivision of Medical Oncology, The Ottawa Hospital, Ottawa, ON, K1H 8L6, CanadaDivision of Cardiology, The Ottawa Hospital, Ottawa, ON, K1H 8L6, CanadaDivision of Medical Oncology, The Ottawa Hospital, Ottawa, ON, K1H 8L6, CanadaDivision of Cardiology, The Ottawa Hospital, Ottawa, ON, K1H 8L6, CanadaA 49-year-old patient with metastatic carcinoma of the bladder and no prior history of heart disease presented with diffuse ST elevation, elevated troponins, and biventricular dysfunction requiring intensive care unit admission and inotropic support after receiving her first course of infusional 5-fluorouracil (5-FU). Over the course of several days, the patient’s cardiac function and clinical status returned to baseline. A follow-up echocardiogram performed 5 days after initial presentation revealed an ejection fraction of 59 percent, with no evidence of wall motion abnormalities. Subsequent 5-FU chemotherapy was discontinued, and the patient went on to receive second-line chemotherapy.http://dx.doi.org/10.1155/2014/819396
spellingShingle Jeffrey Sulpher
Franco Dattilo
Susan Dent
Michele Turek
M. Neil Reaume
Christopher Johnson
Acute Cardiogenic Shock Induced by Infusional 5-Fluorouracil
Case Reports in Oncological Medicine
title Acute Cardiogenic Shock Induced by Infusional 5-Fluorouracil
title_full Acute Cardiogenic Shock Induced by Infusional 5-Fluorouracil
title_fullStr Acute Cardiogenic Shock Induced by Infusional 5-Fluorouracil
title_full_unstemmed Acute Cardiogenic Shock Induced by Infusional 5-Fluorouracil
title_short Acute Cardiogenic Shock Induced by Infusional 5-Fluorouracil
title_sort acute cardiogenic shock induced by infusional 5 fluorouracil
url http://dx.doi.org/10.1155/2014/819396
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AT micheleturek acutecardiogenicshockinducedbyinfusional5fluorouracil
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