GABRP Mediates GABA‐A Receptor to Shape Tumor Immunosuppressive Microenvironment and Promote Tumor Immune Escape and Corresponding Targeted Therapy

GABRP Mediates GABA‐A Receptor to Shape Tumor Immunosuppressive Microenvironment and Promote Tumor Immune Escape and Corresponding Targeted Therapy

ABSTRACT Background Tumor immune evasion mediated by the immunosuppressive tumor microenvironment (TME) remains a major obstacle in cancer therapy. The γ‐aminobutyric acid receptor π subunit (GABRP) is aberrantly expressed in cancers, but its role in immune evasion is poorly defined. Objective To el...

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Bibliographic Details
Main Authors: Wu Cen, Genyuan Fu, Xiaoyu Wang, Ruting Wei, Xingwang Zhou, Wei Teng, Yuanguo Ling, Jiaze Tang, Zhongan Wang, Liangzhao Chu
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Cancer Medicine
Subjects:
cancer cell
GABA receptor
GABRP gene
treatment
tumor microenvironment
Online Access:https://doi.org/10.1002/cam4.70946
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https://doi.org/10.1002/cam4.70946

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