Multi-omics analysis and experiments uncover the link between cancer intrinsic drivers, stemness, and immunotherapy in ovarian cancer with validation in a pan-cancer census

Multi-omics analysis and experiments uncover the link between cancer intrinsic drivers, stemness, and immunotherapy in ovarian cancer with validation in a pan-cancer census

BackgroundAlthough immune checkpoint inhibitors (ICIs) represent a substantial breakthrough in cancer treatment, it is crucial to acknowledge that their efficacy is limited to a subset of patients. The heterogeneity and stemness of cancer render its response to immunotherapy variable, warranting the...

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Main Authors: Yilin Li, Cen Chen, Xiaoyu Ji, Ningxiao Jiang, Fei Wang, Xiangqian Gao, Weiwei Chen, Qiang Tang, Yan Li, Shinan Zhang, Gaofeng Qin, Yingjiang Xu, Yanlin Wang, Lingwen Kong, Lei Han, Jie Mei
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
cancer stemness
intrinsic heterogeneity
immunotherapy therapy
CSE1L
ovarian cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1549656/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1549656/full

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