Lack of neuroprotection after systemic administration of the soluble TNF inhibitor XPro1595 in an rAAV6-α-Syn + PFFs-induced rat model for Parkinson's disease

Lack of neuroprotection after systemic administration of the soluble TNF inhibitor XPro1595 in an rAAV6-α-Syn + PFFs-induced rat model for Parkinson's disease

Parkinson's disease (PD) is characterized by dopaminergic neurodegeneration, α-Synuclein (α-Syn) pathology, and inflammation. Microglia in the substantia nigra pars compacta (SNpc) upregulate major histocompatibility complex class II (MHCII), and variants in genes encoding MHCII affect PD risk....

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Bibliographic Details
Main Authors: Filip Fredlund, Claes Fryklund, Olivia Trujeque-Ramos, Hannah A. Staley, Joaquin Pardo, Kelvin C. Luk, Malú G. Tansey, Maria Swanberg
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Neurobiology of Disease
Subjects:
TNF
Parkinson's disease
Neurodegeneration
Neuroinflammation
α-Synuclein
PFF
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000579
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