Alteration of reactive oxygen species master transcription factor Nrf2 in keratinocytes exposed to monoclonal pathogenic antibody AK23 against desmoglein-3 in pemphigus vulgaris

Alteration of reactive oxygen species master transcription factor Nrf2 in keratinocytes exposed to monoclonal pathogenic antibody AK23 against desmoglein-3 in pemphigus vulgaris

Keratinocytes in mucosal and skin tissues maintain tissue integrity via desmosomes and desmoglein-3 (Dsg3). Pemphigus Vulgaris (PV) is a life-threatening autoimmune blistering disease characterized by autoantibodies against Dsg3, disrupting desmosomes. Nuclear factor erythroid 2–related factor 2 (Nr...

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Bibliographic Details
Main Author: Faris Mohsin Ali Alabeedi
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Autoimmunity
Subjects:
Autoantibodies
autoimmune blistering disease
desmoglein-3
Nrf2
pemphigus vulgaris
Online Access:https://www.tandfonline.com/doi/10.1080/08916934.2024.2377138
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https://www.tandfonline.com/doi/10.1080/08916934.2024.2377138

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