First HPLC-UV method for the determination of homocysteine thiolactone in human urine after derivatization with 1-benzyl-2-chloropyridinium bromide

First HPLC-UV method for the determination of homocysteine thiolactone in human urine after derivatization with 1-benzyl-2-chloropyridinium bromide

Abstract The report presents first high performance liquid chromatography coupled with ultraviolet detection (HPLC-UV) based method for the determination of homocysteine thiolactone (HTL) in human urine. Sample preparation procedure chiefly involves chloroform liquid-liquid extraction of HTL and its...

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Bibliographic Details
Main Authors: Marta Gaweł, Rafał Głowacki, Justyna Piechocka
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Homocysteine Thiolactone
Liquid-liquid extraction
Reversed phase liquid chromatography
Ultraviolet detection
Urine
1-benzyl-2-chloropyridinium bromide
Online Access:https://doi.org/10.1038/s41598-025-92323-y
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https://doi.org/10.1038/s41598-025-92323-y

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