Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells

Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells

Abstract Pathogenic antibodies produced by alloreactive B cells mediate antibody-mediated rejection after kidney transplantation, but the mechanisms remain poorly understood. Follicular regulatory T (Tfr) cells modulate follicular helper T cell-mediated B cell responses, but the functions of Tfr in...

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Main Authors: Hengcheng Zhang, Manuel A. Podestà, Cecilia B. Cavazzoni, Yumeng Wu, Jeong-Mi Lee, Xiaofei Li, Paulo Lisboa Raeder, Pragya Chandrakar, Maya Gempler, Sierra Richardson, Deepjyoti Ghosh, Ismail Sayin, Bruce R. Blazar, Reza Abdi, Astrid Weins, Anita S. Chong, Peter T. Sage
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57468-4
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https://doi.org/10.1038/s41467-025-57468-4

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