Optimizing glycerosome formulations via an orthogonal experimental design to enhance transdermal triptolide delivery
Triptolide exerts strong anti-inflammatory and immunomodulatory effects; however, its oral administration might be associated with side effects. Transdermal administration can improve the safety of triptolide. In this study, glycerosomes were prepared as the transdermal vehicle to enhance the transd...
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| Format: | Article |
| Language: | English |
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Sciendo
2022-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2022-0006 |
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| author | Zhu Chunyun Zhang Yongtai Wu Tong He Zehui Guo Teng Feng Nianping |
| author_facet | Zhu Chunyun Zhang Yongtai Wu Tong He Zehui Guo Teng Feng Nianping |
| author_sort | Zhu Chunyun |
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| description | Triptolide exerts strong anti-inflammatory and immunomodulatory effects; however, its oral administration might be associated with side effects. Transdermal administration can improve the safety of triptolide. In this study, glycerosomes were prepared as the transdermal vehicle to enhance the transdermal delivery of triptolide. With entrapment efficiency and drug loading as dependent variables, the glycerosome formulation was optimized using an orthogonal experimental design. Phospholipid-to-cholesterol and phospholipid-to-triptolide mass ratios of 30:1 and 5:1, respectively and a glycerol concentration of 20 % (V/V) were used in the optimization. The glycerosomes prepared with the optimized formulation showed good stability, with an average particle size of 153.10 ± 2.69 nm, a zeta potential of –45.73 ± 0.60 mV and an entrapment greater than 75 %. Glycerosomes significantly increased the transdermal delivery of triptolide compared to conventional liposomes. As efficient carriers for the transdermal delivery of drugs, glycerosomes can potentially be used as an alternative to oral triptolide administration. |
| format | Article |
| id | doaj-art-f1ed07f1fde84ffba78afdd2f97492a6 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-f1ed07f1fde84ffba78afdd2f97492a62025-02-02T02:10:54ZengSciendoActa Pharmaceutica1846-95582022-03-0172113514610.2478/acph-2022-0006Optimizing glycerosome formulations via an orthogonal experimental design to enhance transdermal triptolide deliveryZhu Chunyun0Zhang Yongtai1Wu Tong2He Zehui3Guo Teng4Feng Nianping5Department of Pharmaceutical Sciences, Shanghai University of Traditional, Chinese Medicine, Shanghai 201203, ChinaDepartment of Pharmaceutical Sciences, Shanghai University of Traditional, Chinese Medicine, Shanghai 201203, ChinaDepartment of Pharmaceutical Sciences, Shanghai University of Traditional, Chinese Medicine, Shanghai 201203, ChinaDepartment of Pharmaceutical Sciences, Shanghai University of Traditional, Chinese Medicine, Shanghai 201203, ChinaDepartment of Pharmaceutical Sciences, Shanghai University of Traditional, Chinese Medicine, Shanghai 201203, ChinaDepartment of Pharmaceutical Sciences, Shanghai University of Traditional, Chinese Medicine, Shanghai 201203, ChinaTriptolide exerts strong anti-inflammatory and immunomodulatory effects; however, its oral administration might be associated with side effects. Transdermal administration can improve the safety of triptolide. In this study, glycerosomes were prepared as the transdermal vehicle to enhance the transdermal delivery of triptolide. With entrapment efficiency and drug loading as dependent variables, the glycerosome formulation was optimized using an orthogonal experimental design. Phospholipid-to-cholesterol and phospholipid-to-triptolide mass ratios of 30:1 and 5:1, respectively and a glycerol concentration of 20 % (V/V) were used in the optimization. The glycerosomes prepared with the optimized formulation showed good stability, with an average particle size of 153.10 ± 2.69 nm, a zeta potential of –45.73 ± 0.60 mV and an entrapment greater than 75 %. Glycerosomes significantly increased the transdermal delivery of triptolide compared to conventional liposomes. As efficient carriers for the transdermal delivery of drugs, glycerosomes can potentially be used as an alternative to oral triptolide administration.https://doi.org/10.2478/acph-2022-0006nanocarriersliposomesglycerosomestransdermalrheumatoid arthritis |
| spellingShingle | Zhu Chunyun Zhang Yongtai Wu Tong He Zehui Guo Teng Feng Nianping Optimizing glycerosome formulations via an orthogonal experimental design to enhance transdermal triptolide delivery Acta Pharmaceutica nanocarriers liposomes glycerosomes transdermal rheumatoid arthritis |
| title | Optimizing glycerosome formulations via an orthogonal experimental design to enhance transdermal triptolide delivery |
| title_full | Optimizing glycerosome formulations via an orthogonal experimental design to enhance transdermal triptolide delivery |
| title_fullStr | Optimizing glycerosome formulations via an orthogonal experimental design to enhance transdermal triptolide delivery |
| title_full_unstemmed | Optimizing glycerosome formulations via an orthogonal experimental design to enhance transdermal triptolide delivery |
| title_short | Optimizing glycerosome formulations via an orthogonal experimental design to enhance transdermal triptolide delivery |
| title_sort | optimizing glycerosome formulations via an orthogonal experimental design to enhance transdermal triptolide delivery |
| topic | nanocarriers liposomes glycerosomes transdermal rheumatoid arthritis |
| url | https://doi.org/10.2478/acph-2022-0006 |
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