Ex vivo and in vivo HIV-1 latency reversal by “Mukungulu,” a protein kinase C-activating African medicinal plant extract

Ex vivo and in vivo HIV-1 latency reversal by “Mukungulu,” a protein kinase C-activating African medicinal plant extract

ABSTRACT New HIV latency-reversing agents (LRAs) are needed that can reactivate and/or eliminate HIV reservoirs. “Mukungulu,” prepared from the plant Croton megalobotrys Müll Arg., is traditionally used for HIV/AIDS management in northern Botswana despite an abundance of protein kinase C-activating...

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Main Authors: Khumoekae Richard, Zhe Yuan, Hsin-Yao Tang, Aaron R. Goldman, Riza Kuthu, Boingotlo Raphane, Emery T. Register, Paridhima Sharma, Brian N. Ross, Jessicamarie Morris, David E. Williams, Carol Cheney, Guoxin Wu, Karam Mounzer, Gregory M. Laird, Paul Zuck, Raymond J. Andersen, Sundana Simonambango, Kerstin Andrae-Marobela, Ian Tietjen, Luis J. Montaner
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
HIV
latency reversal
natural products
traditional medicines
ex vivo
humanized mice
Online Access:https://journals.asm.org/doi/10.1128/mbio.03816-24
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https://journals.asm.org/doi/10.1128/mbio.03816-24

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