Anti-citrullinated histone monoclonal antibody CIT-013, a dual action therapeutic for neutrophil extracellular trap-associated autoimmune diseases

Anti-citrullinated histone monoclonal antibody CIT-013, a dual action therapeutic for neutrophil extracellular trap-associated autoimmune diseases

Neutrophil extracellular traps (NETs) contribute to the pathophysiology of multiple inflammatory and autoimmune diseases. Targeting the NETosis pathway has demonstrated significant therapeutic potency in various disease models. Here, we describe a first-in-class monoclonal antibody (CIT-013) with hi...

Full description

Saved in:
Bibliographic Details
Main Authors: Maarten van der Linden, Sangeeta Kumari, Daphne Montizaan, Stephanie van Dalen, Annemarie Kip, Martyn Foster, Inge Reinieren-Beeren, Elsa Neubert, Luise Erpenbeck, Kelsy Waaijenberg, Tirza Bruurmijn, Rezie te Poele, Peter van Zandvoort, Paul Vink, Eric Meldrum, Helmuth van Es, Renato G.S. Chirivi
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Citrullinated histones
mechanism of neutrophil extracellular trap inhibition
neutrophil extracellular trap phagocytosis
rheumatoid arthritis
therapeutic monoclonal antibody
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2281763
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2023.2281763

Similar Items