Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

Abstract The mitochondrial calcium uniporter (MCU) complex mediates Ca2+ entry into mitochondria, which plays a crucial role in regulating cellular energy metabolism and apoptosis. Dysregulation of MCU is implicated in various diseases, such as neurodegenerative disorders, cardiac diseases, and canc...

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Main Authors: Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu, Guangqin Liu, Jun Gao, Jiayi Chen, Ting Li, Dingyi Lu, Lingmin Zeng, Haizhen Zhu, Weina Zhang, Qing Xia, Teng Li, Tao Zhou, Xue‐Min Zhang, Ai‐Ling Li, Xin Pan
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
berberine
EMRE
MCU (mitochondrial calcium uniporter)
mitochondrial calcium signaling
myocardial injury
small molecules
Online Access:https://doi.org/10.1002/advs.202412311
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https://doi.org/10.1002/advs.202412311

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