Screening and discovery of an antiviral candidate inhibiting the SARS-CoV-2 envelope (2-E) channel

Screening and discovery of an antiviral candidate inhibiting the SARS-CoV-2 envelope (2-E) channel

The SARS-CoV-2-encoded 2-E channel is critical in the viral life cycle and pathogenesis. By facilitating viral replication, it promotes the dysregulation of inflammatory pathways, leading to cytokine storm, and triggers DNA damage response (DDR), thus exacerbating disease progression. The 2-E channe...

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Bibliographic Details
Main Authors: Han Zhang, Shuxin Shi, Lujia Sun, Shuangqu Li, Yan Zhang, Ziyue Li, Jingjing Hou, Pingan Li, Jingshan Shen, Xi Cheng, Shibo Jiang, Zhaobing Gao, Xinling Wang, Xiangrui Jiang, Bingqing Xia
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Research in Microbial Sciences
Subjects:
SARS-CoV-2 envelope protein
Viroporin
Fluorescence release
Antivirus
Drug target
Online Access:http://www.sciencedirect.com/science/article/pii/S2666517425000719
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