tRF16 affects NFKBIA stability and promotes osteoarthritis progression by regulating ALKBH5 expression in m6A-dependent manner

Abstract This study aimed to investigate explore the role of tRF16-ALKBH5 in osteoarthritis (OA). Differential expression of tRF in normal and OA tissues was analyzed using sequencing. OA rats model was established by destabilization of the medial meniscus and anterior cruciate ligament transaction...

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Bibliographic Details
Main Authors: Chunhui Zhu, Gang Liu, Weibo Zhou, Yaojun Lu, Wei Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08299-y
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