Potential Protective Effect of Orlistat: A Formulation of Nanocrystals Targeting Inflammation, Oxidative Stress, and Apoptosis in an Experimental Model of Doxorubicin-Induced Cardiotoxicity

Potential Protective Effect of Orlistat: A Formulation of Nanocrystals Targeting Inflammation, Oxidative Stress, and Apoptosis in an Experimental Model of Doxorubicin-Induced Cardiotoxicity

<b>Background</b>: Doxorubicin (DOX) is a widely used chemotherapeutic agent; nevertheless, cardiotoxicity limits its effectiveness. Orlistat (Orli) is an irreversible lipase enzyme inhibitor with poor solubility and bioavailability. Furthermore, Orli has a favorable impact on the decrea...

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Bibliographic Details
Main Authors: Maha Alsunbul, Thanaa A. El-Masry, Enas I. El Zahaby, Mohamed M. S. Gaballa, Maysa M. F. El-Nagar
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Pharmaceutics
Subjects:
cardioprotective
orlistat nanocrystals
oxidative stress
inflammation
apoptosis
Sirt-1
Online Access:https://www.mdpi.com/1999-4923/16/11/1356
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